Dr. Robert B. Stein, also known as Bob, Ph.D., M.D. has been Senior R&D Advisor at Agenus Inc. since April 1, 2017 an served as its President of Research and Development from September 2015 to April 1, 2017. Dr. Stein serves as scientific adviser to Takeda Pharmaceutical Co. Ltd. Dr. Stein has over 30 years of experience and accomplishments to the Agenus leadership team. He is an innovative and experienced executive with deep, broad knowledge of biology, medicine and pharmaceutical science. Dr. Stein lead Agenus' Research, Pre-clinical Development and Translational Medicine functions and guide the company's clinical development. In addition, pending closing, Dr. Stein play a critical role in leading the integration of the 4-Antibody acquisition announced today, which includes the company's fully human antibody drug discovery and optimization technology platform and portfolio of immune checkpoint antibody programs. Dr. Stein served as the Chief Executive Officer of KineMed, Inc. since August 01, 2008. Dr. Stein served as President of Roche Palo Alto from 2003 to 2006. Dr. Stein served as President and Chief Scientific Officer of Incyte Corporation since November 2001 until August 22, 2003. He served as Chief Scientific Officer at Agenus Inc. since February 2014 until January 27, 2016. Dr. Stein served as Executive Vice President of Research and Preclinical Development of DuPont Pharmaceuticals Company, formerly The DuPont Merck Pharmaceutical Company, from 1990 to November 2001. Dr. Stein has over 25 years of experience in research and development and business roles with pharmaceutical and biotechnology companies. He served as Executive Vice President of Research and Pre-clinical Development from 1990 to 1996. Dr. Stein served as Senior Vice President and Chief Scientific Officer from May 1990 to September 1996 and Vice President of Research and Preclinical Development from 1992 to 1993 and Vice President of Research for Ligand Pharmaceuticals, Inc. from 1990 to 1992. Dr. Stein spent the early part of his career at Merck, Sharp and Dohme Research Laboratories. He was Senior Vice President of Research for Ligand Pharmaceuticals. He held various positions with Merck & Co., Sharp & Dohme Research Laboratories from 1982 to 1990, which included Senior Director and Head of the Department of Pharmacology from 1989 to 1990. Dr. Stein serves on the President's Board of Advisors for Science and Innovation for the University of California. Dr. Stein has been Director of Archemix Corp. since April 03, 2007. He has been a Director of Atrinsic, Inc. since February 12, 2016. He serves as a Director of Incyte Genomics. He served as a Director of diaDexus, Inc. He served as a Director of KineMed, Inc. since August 1, 2008. He served as Director of Incyte Corporation from 2001 to August 21, 2003. He served as Director of Geron Corporation from April 1996 to September 2, 2003. He completed residency training and is board certified in anatomic and clinical pathology. Dr. Stein holds B.S. in Biology and Chemistry from Indiana University. He also holds M.D. and Ph.D. in Physiology and Pharmacology from Duke University.