Dr. Bruce D. Given, M.D., has been the Chief Operating Officer at Arrowhead Research Corp., (alternate name Arrowhead Pharmaceuticals, Inc.) since October 26, 2011 and serves as its Managing Director. Dr. Given serves as an Advisor of InCube Labs, LLC. He serves as Healthcare Products Consultant and Principal at Bruce Given Consulting. He served as Head of R&D at Arrowhead Research Corp. He has over 17 years experience in the pharmaceutical industry. He served as the Chief Executive Officer at Leonardo Biosystems, Inc. since February 1, 2010. He was with Johnson & Johnson for nine years. He served as an Acting Chief Medical Officer at SemBioSys Genetics Inc. He served as the Chief Executive Officer and President at Encysive Pharmaceuticals Inc., (formerly Texas Biotechnology Corp.) from March 2002 to June 2007. He served as Vice President of Clinical Development at Encysive Pharmaceuticals Inc. since June 26, 2006. Dr. Given joined Encysive Pharmaceuticals Inc., after serving as the President of International of Ortho-Clinical Diagnostics of Johnson & Johnson from May 2000 to March 2002. He served as the General Manager at Transfusion Medicine Worldwide of Ortho- Clinical Diagnostics from November 1999 to May 2000. He served as a Group Vice President, Head of Worldwide Clinical and Regulatory Affairs at Biosense Webster, an affiliate of Johnson & Johnson from July 1998 to November 1999. He served as a Group Vice President, Head of U.S. Marketing & Sales, Research & Development at Janssen Pharmaceutica from April 1995 to July 1998. He held various executive and senior management positions with Sandoz Pharma Ltd., Sandoz Research Institute and Schering-Plough Corporation. He is Secretary of the Executive Committee of the Board and the Texas Life Science Center. He served as the Chairman of ICON Public Limited Company from January 1, 2010 to December 31, 2012. He served as the Chairman of the Rider University Scientific Advisory Board. Dr. Given serves as a Member of Board of Advisors at InCube Ventures, LLC. He serves as a Member of Scientific Advisory Board at Vapogenix, Inc. He serves as a Director for the Texas Life Science Center. He serves as a Director at Pulmotect, Inc. He has been a Director of SemBioSys Genetics Inc. since June 2011. He serves as a Member of the inCube Scientific Advisory Board. Dr. Given served as an Independent Director of ICON Public Limited Company PLC from September 1, 2004 to July 22, 2013. He served as a Director of Calando Pharmaceuticals, Inc., since November 2009. He served as a Director of Encysive Pharmaceuticals Inc. from March 2002 to July 16, 2007. He served as the Medical Faculty at the University of Chicago. He is board certified in internal medicine and endocrinology and metabolism and has authored 33 scientific publications. His honors include the Franklin McLean Research Award from the University of Chicago, election to Alpha Omega Alpha and the Provost Award from Colorado State University. Dr. Given holds a B.S. degree from Colorado State University graduating Phi Beta Kappa. He holds an M.D. with honors from the University of Chicago, Pritzker School of Medicine in 1980 and completed his medical training at the University of Chicago and at Brigham and Women's Hospital in Boston where he was a Clinical Fellow at Harvard Medical School.