Mr. Patrick L. Keran, also known as Pat, JD, has been General Counsel of SeaSpine Holdings Corporation since October 12, 2015 and has been its Corporate Secretary since June 2016. Mr. Keran serves as a Vice President at SeaSpine Holdings Corporation. He served as the President and Chief Operating Officer of Mast Therapeutics, Inc. from February 2010 to February 28, 2015 and as its Secretary since September 8, 2006. Mr. Keran has over 15 years of legal and operational experience, primarily with respect to capital raising, corporate governance and FDA-regulated entities. Mr. Keran served as the Principal Financial Officer of Mast Therapeutics, Inc. (also known as Adventrx Pharmaceuticals, Inc.) since July 2009 until January 2013 Principal Accounting Officer from July 2009 to March 22, 2011. He served as a General Counsel of Adventrx Pharmaceuticals Inc. from August 9, 2006 to February 2010 and also served as its Vice President of Legal from January 2007 to February 2010. He served as an Interim Principal Financial Officer and Interim Principal Accounting Officer of Mast Therapeutics, Inc. since July 2009 and Vice President since January 2007. He joined Adventrx Pharmaceuticals, Inc. in August 2006. He served as an Associate General Counsel for Isis Pharmaceuticals, Inc. from April 2004 to August 2006. Before that, he practiced corporate and commercial law at the law firms Heller Ehrman, LLP from February 2003 to April 2004 and Brobeck, Phleger & Harrison LLP from September 1999 to February 2003. Mr. Keran is licensed to practice law in the State of California. Mr. Keran received a B.A. from the University of California at San Diego and a J.D. from the University of California at Berkeley, Boalt Hall School of Law.