The job typically requires expanding out of one's role far too often and can become overwhelming. Most roles on site are typically thankless so one can definitely feel jaded along with the paltry merit increases.
Lack of direction and synergy from all levels of the company. Most if not all the time the sites are left to fend for themselves without adequate coverage, which puts even more stress on the on site team. Expectations are too high without recieving the tools to succeed.