Empatica FAQs

To check if everything is working correctly, open the Alert App and take a look at the status bar at the top of main page.

A green check mark means that Embrace is working as it should be.

Battery low

Other statuses that you may encounter:

No internet connection

Bluetooth is off

Embrace not found

Memory full

No data recordedis meant to appear on days where Embrace wasn't worn.

If you receive this message on a day in which you're certain you wore Embrace,please check the following:

Make sure the memory on Embrace isn't full. To check this go to the Alert App > More > Embrace Settings > Embrace Memory. To free up your Embrace memory, check: Yellow Cross / Memory Full

Make sure there is no data to be uploaded from your smartphone to the cloud. You can check this by going to the Alert App > More > Embrace Settings > Data Stored in App. To free up space in the Alert App, just make sure the phone is connected to internet and the data should transfer automatically. If nothing is transferred after 20 minutes, toggle off and on Upload using Wi-Fi only.

If all of the above are fine, we recommend killing both the Alert and Mate App and relaunching. This will give them a reset and should enable the transfer of data.

Please note that when viewing your data for the first time, it can take up to 30 minutes to one hour for the data from your Embrace to sync up with the Mate App.

In the morning, immediately upon waking it may take around 30 minutes to up to an hour to see your rest stats and analysis in the Mate App.

This is because our algorithms need to be sure that you are fully awake and its not just an interruption in your rest period.

Embrace detects walking and running. When there is a significant amount of movement, but distance remains relatively low, it classifies this as sport.

It takes at least 5 consecutive minutes of walking for the activity to be classified. For running and sport, the threshold is 10 minutes.

Therefore, if you walk 3 minutes around your house, you will not see it as walking on the graph. However, it will be reflected in the total step count for the day.

High and low intensity activity

Embrace calculates physical activity based on wrist movement. This means that intense activities such as weight lifting, yoga or spinning, may not be classified as high intensity.

Distance displayed is not exact

Mate's calculations may differ from your GPS fitness tracker because the data is computed using wrist accelerometer data. It does not contain GPS functionalities.

Beyond this it also takes into account the step count, distance, height, and gender to calculate the distance.

If you have a very small or large stride this could affect the calculation of the distance. In this case, it may be more rely on the step count.

If the white and blue lights do not appear after you single tap the cover, make sure that Embrace is charged and the Lights and Vibration havenot been deactivated.

If you try to tap on the cover, but you're not wearing Embrace or it's worn very loosely on the wrist, the LEDs won't light up.

If all of the above are fine, please reach out to us at [email protected] and well try to resolve the issue as quickly as we can.

Notifications from the Alert App allow you to receive important information about Embrace and the Alert service directly on your paired smartphone or device. These include low battery warnings, disconnections, whether a caregiver has confirmed your alert, no internet connection, and more.

Recurrent notifications

Certain notifications are critical to safely using Embrace. Weve made these notifications recurrent so youdon'tmiss them and can quickly take action. However, we also understand that there may be certain times in which you'd like to deactivate the recurrent notifications.

To deactivate recurrent notifications follow the instructions below:

Open the Alert App

Tap on the More tab

Go to Embrace Settings

Then tap on Notifications

Toggle off Recurrent notifications

If you feel that youre not receiving notifications, it may be that you didnt give the Alert App permission to push them.

To fix this:

Go to your phones general settings

Then go to Notifications (or Apps and Notifications for Android)

Find Alert App

Toggle on Alert Notifications (or Show notifications for Android)

Embrace needs to be connected via Bluetooth to a dedicated smartphone that is always with the user.

There are three main reasons for disconnections:

Your Embrace is out of range from your paired phone.

Some interference is obstructing the Bluetooth connection.

Embrace is connected via Bluetooth to more than one phone.

Embrace out of range

If the distance between Embrace and the paired smartphone exceeds 30ft/10m, the Bluetooth connection will be lost. Moving the smartphone and Embrace closer together should automatically resolve the issue. This distance could be shorter if there are obstructions such as walls, doors, etc., or radio interference from other bluetooth devices.

Tip: Some users might find it tricky to keep Embrace within the bluetooth range of the paired smartphone, especially if the Embrace user is a young child. In this case, we suggest using a running belt to carry the smartphone which will ensure that the two devices are always in range.

Bluetooth interference

Large obstacles and anything that transmits radio signals can obstruct the bluetooth signal. For example, walls, large furniture, thick pillows, and even your own body can lead to disconnections (e.g., crossing arms). In general, always try to keep the smartphone as close to Embrace as possible and within a clear line of sight.

Embrace is connected via Bluetooth to more than one phone

Embrace should only be paired with one phone at a time. Its possible that after disconnecting Embrace from the Alert app, it still remains in the bluetooth settings of the previous phone. Please make sure to check the bluetooth settings of any other phonesyou'vepreviously paired Embrace with.

To change the phone Embrace is paired with you'll have to unpair it from the smartphone it is current paired with, and then pair it with the new phone.To do this:

Delete the Alert App from the old phone.

Forget (unpair) Embrace from the Bluetooth settings of the old phone ( iOS devices, Android devices ).

Turn off the Bluetooth on the old phone.

Download the Alert App on the new smartphone.

Sign in with the same email address and password.

Pair your Embrace with the new smartphone by going to the More tab > Embrace Settings > Restore pairing.

Please keep in mind that Embrace must be paired with only one phone at a time. Dont forget to check the Bluetooth settings of your old phone to make sure its no longer listed as a device. If it is, please repeat step 2.

If the lights and vibration bother you, you can deactivate them by following the instructions below:

Open the Alert App

Go to the Embrace tab

Toggle off Light& Vibration

Please note that deactivating this feature means that you'll have to rely on the app for important information about Embrace such as when it's disconnected, has a low battery or when the memory is full.

iOS 13 introduces several changes to location data and permissions. As such, weve modified the Alert app to be in line with these new requirements.

First, its important to know that the Alert app only uses your location to send your GPS coordinates to caregivers, when a possible tonic-clonic seizure is detected (Note: this feature is only available with the Standard and Plus subscription plan).

Outside of sending alerts, your location will not be tracked, nor will it be shared with anyone.

In order for the Alert app to send your location to caregivers when a seizure is detected, access to Location must always be enabled and set to "always".

Follow the below instructions to always allow access:

Onceyou'veupdated to iOS 13, youll be asked to allow the Alert app to access your location.

[email protected]

Tap Allow While Using App.

Then the next page asks you to go to your settings to always allow location.

Tap Go to Settings.

Tap Always.

Another change youll notice is requesting permission to access Bluetooth. Embrace cannot work without being connected to your phone, and it uses Bluetooth to connect.

Here is how to allow access to Bluetooth:

When you open the Alert app after updating to iOS 13, youll be asked if you want to allow the Alert app to use Bluetooth.

Tap OK.

If you accidentally dismissed the messages or want to double-check that your settings are correct, just go to your General Settings > Alert App. They should look like this:

If you have any questions, please write to us at

Getting Embrace reimbursed by insurance depends on your specific plan and coverage level.

Asking your doctor to fill out this form may improve your chances of a reimbursement:

Embrace2 Predetermination template

If your doctor would like more information about Embrace, you can direct them to the dedicated page that we've created for doctors on our website, providing them with all of the necessary information they need to know.

In addition, your doctor may be interested in the below articles:

FDA Clearance Summary

Epilepsia 2017 journal results

We suggest contacting your insurance agent directly for any questions regarding insurance coverage of the subscription plan.

If you submit a request to get your Embrace or the subscription plan costs reimbursed, please let us know about the outcome so that with this knowledge, we can help the Embrace community.

FSA Cards (Flexible Savings Account)

We accept payment by FSA card (Flexible Savings Account). Your benefits administrator may ask you for an official invoice to validate that the purchase of Embrace was an eligible expense. Its possible that they might also ask for the prescription from your doctor. You can simply email us to request these at [email protected].

Getting Embrace into the hands of those that need it most, regardless of income level is extremely important to us. Were constantly looking for, and meeting with organizations to partner with on this endeavor.

Below are the charities we're currently partnering with. You can reach out to them to inquire about a donated or discounted Embrace.

USA

Epilepsy Foundation New England (supporting onlyNH, ME, MA, and RI)

Danny Did

Briezy's Bunch

Caregiver Healing Foundation

Chelsea Hutchison Foundation

Epilepsy Foundation of Vermont

Isaiah Stone Foundation

Hearts of Epilepsy

UK

Epilepsy Sucks UK

Australia

Epilepsy Action Australia

Epilepsy Western Australia

Canada

BC Epilepsy Society

What is a Caregiver?

As a Caregiver, you'll be the person responsible for providing assistance when Embrace detects an unusual pattern associated with a tonic-clonic seizure. We highly encourage you to set up an emergency action plan with the user so you can quickly assist them. If you choose not to accept this responsibility, please reach out to them asking to be removed from the Alert App.

What are your responsibilities?

If you receive an alert call or SMS, this means that the Embrace wearer could be having a tonic-clonic seizure, which generally includes going stiff, losing consciousness, falling to the floor, and also jerks and convulsions.

How do alerts work?

When the Embrace detects an unusual event associated with a tonic-clonic seizure, it communicates to the Alert App to send a phone call and SMS to the wearer's activated Caregivers. Its possible that you may also receive the GPS location in the SMS depending on the user's subscription plan. You can check with them if they have this feature. We send out Alerts from +1 (415) 498-1544. Please save this number as some cellular service carriers have been known to block calls from unknown numbers.

Texts can come from any of the following numbers. We recommend saving all of them to your phone:

+1 (833) 969-1366

+1 (833) 969-1322

+1 (833) 955-1403

+1 (833) 955-1354

+1 (587) 801-5461

For more information on this process, please read this article: How Embrace works

Instructions for receiving Alerts

When you receive the alert call, an automated message will play and ask you to press "1" confirming you heard the message. Make sure that you've established an emergency plan with the wearer ahead of time.

[email protected].

In these articles you can find some tips on how to assist your loved ones during a seizure:

Seizure First Aid

General First Aid for All Seizure Types

Not receiving Alert calls

If you do not receive Alert calls even if your number has been activated, or if the calls go directly to voicemail, please email us at [email protected] so that we can look into it.

Please note that some mobile carriers provide scam block services that might misidentify the number from which the Alert calls are placed as possible scam and the calls might be automatically dropped. Please make sure to disable the scam block feature if this is the case.

False Alarms

Some activities such as riding a bike on a bumpy road, chopping vegetables, or brushing teeth, resemble the movement signature of a seizure, and can trigger false alarms. If the user doesnt cancel false alarms on time, you will receive an automated call and SMS.

The user can also notify you through the Alert App to let you know it wasn't a seizure.

Added as a Caregiver by mistake

If you don't know the user that has added you or feel you've been added by mistake, just email us at Please include your phone number in the email.

A caregiver is someone who will receive an automatic call and SMS upon the detection of a possible convulsive seizure. Although the alerts can be delivered to caregivers at any distance, we suggest that caregivers are nearby so that they are able to assist in a timely manner. Caregivers do not need to have internet connection, and theydon'tneed to install the Alert App on their phone. The only thing they need is a working phone signal, as alerts can also be sent to landline phones.

To add caregivers:

1. Open the Alert App and tap on the Caregivers tab at the bottom of the screen.

subscription plan

2. Tap on the + sign on the next screen to add a Caregiver.

3. Enter the information required - name, country, phone number, and email address.

4. Tap on Save Caregiver.

To enter the phone number of the caregiver, tap on phone and select the country from the drop down. The country dial code automatically populates, you only need to enter the remaining digits of the phone number.

The caregivers contact can also be added directly through a search in the phones address book. Please bear in mind that phone numbers should be added without the zero in the front.

You can activate and deactivate caregiver based on whos available and nearby. For example in the case of children, the parents could be activated as caregivers in the morning, the teacher at school during school hours, the nanny after school and the parents in the night. This ensures that the Embrace user is covered at all times.

You need to have at least 1 Caregiver activated so that they can be notified when Embrace detects a possible convulsive seizure. You can activate a Caregiver by tapping on the toggle button next to their name.

Caregivers should save the alert number to avoid any calls being blocked by their cellular service carrier. The alert number is: 1 (415) 498- 1544.

Texts can come from any of the following numbers. We recommend saving all of them to your phone:

+1 (833) 969-1366

+1 (833) 969-1322

+1 (833) 955-1403

+1 (833) 955-1354

+1 (587) 801-5461

The number of Caregivers that can be activated varies based on the you choose.

Lite plan: You can activate 1 Caregiver at a time. The activated Caregiver will receive a phone call and an SMS when Embrace detects a possible convulsive seizure. Please note that you can add unlimited Caregivers but activate one at a time.

Standard plan: You can activate up to 3 Caregivers at a time. They will be notified simultaneously via phone call and SMS. Please note that you can add unlimited Caregivers but activate three at a time.

Plus plan: You can activate an unlimited number of Caregivers with this plan.

Unlimited Caregivers feature is also available as an add-on.

Embrace can be paired with most modern smartphones and/or tablets.

The minimum requirements are:

-iOS devices running iOS 10 or later.

-Android devices running Android version 5.0 (Lollipop or higher) and with Bluetooth Low Energy (BLE 4.0/Bluetooth smart).

Please note: There is plenty of variation between how different Android devices handle the technologies used in our products and services, such as Bluetooth Low Energy (BLE). Because of this, we cannot guarantee compatibility with all devices that meet the above requirements .

Other mobile platforms

We do not support Windows and Blackberry phones.

We are available to answer your questions between9:00 AM 5:00 PM EST (Eastern Standard Time), Monday - Friday at +1 (866) 739-2049.

If you want to reach us outside of these hours, please contact us by submitting a request or sending us an email at [email protected] and we'll respond as soon as we can.

Embrace is optimized to detect movement patterns and autonomic arousal lasting at least 20 seconds. These characteristics are generally associated with convulsive or tonic-clonic seizures.

Wecan'tguarantee that Embrace will detect every single seizure. It is not meant to substitute your current seizure monitoring practices, but rather to serve as a supplement in expediting first-response time.

Weve developed an additional feature called Rest Mode that is meant to be used during sleep or periods of rest. Its more sensitive so it can better detect milder convulsive activity. This feature is available with our Standard and Plus subscription plans.

In the US, Rest Mode is set as the default mode as it has been cleared by the FDA, and it's included in every subscription plan. Turning off Rest Mode means that you will be using a version of the device that hasnt been FDA-cleared.

At the moment Embrace is not designed to alert forother types of seizures, such as:

Complex partial seizures

Someone experiencing this type of seizure may seem confused and may have difficulty responding to questions for a few minutes. Embraceisn'tdesigned to alert for these types of seizures because they usually do not generate convulsions.

Absence seizures

These seizures generally do not show any movements. Instead they cause rapid blinking or staring into space. Embrace cannot alert for them as they do not generate significant motion and autonomic responses.

Nonconvulsive seizures

Currently, Embrace cannot alert for nonconvulsive seizures as the specific movement signature of convulsions takes precedence in our algorithm. EDA also takes part in our algorithm, but since it is more prone to fluctuate, relying too heavily on it would result in more false alarms.

Embrace cannot predict or prevent seizures.

Our technology is designed to detect patterns that could be associated with tonic-clonic seizures lasting longer than 20 seconds. To learn more, check out the types of events Embrace can detect.

There shouldn't be any problems using Embrace with the stretchable band alongside a VNS as Embrace does not contain any magnetic parts. If instead, youd like to use the Vegan Leather Band, we suggest checking this with your doctor because it contains magnetic parts.

The VNS could actually be great to use alongside Embrace, because it activates the parasympathetic branch of the autonomic nervous system. Embrace measures electrodermal activity which is a common measure of autonomic nervous system activity.

Embrace comes with an app called Mate. Mate tracks your physical activity and provides an in-depth rest analysis.

We've based our rest analysis algorithm off of the following studies:

Landry et al (2015) Measuring sleep quality in older adults: a comparison using subjective and objective methods

Aubert-Tulkens et al (1987) Ambulatory Evaluation of Sleep Disturbance and Therapeutic Effects in Sleep Apnea Syndrome by Wrist Activity Monitoring

Patel et al (2015) Reproducibility of a Standardized Actigraphy Scoring Algorithm for Sleep in a US Hispanic/Latino Population

R. J. Cole, et al (1992) Automatic sleep/wake identification from wrist activity"

Ohayon et al (2004) Meta-Analysis of Quantitative Sleep Parameters From Childhood to Old Age in Healthy Individuals: Developing Normative Sleep Values Across the Human Lifespan

Read more about Mate's analysis of rest here.

We are constantly validating and improving our algorithm, and to test its accuracy we collaborate with top hospitals.

In December 2018, clinical testing was performed to demonstrate the ability of the Embrace as a seizure monitoring aid.

During the clinical testing, 141 patients diagnosed with epilepsy were continuously monitored. This lead to 9806 hours or 409 days of data, including 54 generalized tonic-clonic seizures. The trial was supervised by 3 board-certified clinical neurologists who independently examined the data. Embrace's algorithm was shown to detect 98% of the seizures, and the false alarm rate was 0.94 per day.

The full details of this work are included in this document, in the section titled, Clinical Testing.

We built Embrace with the highest quality materials to ensure that it passes all the FDA-required tests (specified in ISO 10993) for biocompatibility. It is therefore very unlikely that you'll develop an allergic reaction from Embrace.

However, some people may still notice a slight reaction on their skin. If this happens, please contact our support team ( [email protected] ) with a photo of the irritation.

Important notes

Embrace should only be worn on the surface of healthy skin. We advise that you suspend or discontinue use if the skin becomes red, itchy or if any pain is felt.

Without regular cleaning, skin irritation is more likely to occur, so please make sure to clean Embrace regularly.

Materials used

If you are allergic to the following materials, we don't recommend wearing Embrace:

Top Cover:

Housing: Anodized aluminum

Light ring: Polycarbonate (PC) light pipe

Bottom cover:

Base: Polycarbonate (PC) base

Electrodes: SUS316L electrodes (Standard material for watch cases and some jewelry. Can cause minor reactions in those with very sensitive skin.)

Screws: 304 Stainless Steel

Band Frame

Original Embrace: Aluminum, nickel-free chrome plated

Embrace2: Stainless steel, Chromium Nitride PVD coating

Stretchable Band

Polyester

Polyurethane

Aluminium, nickel-free chrome plated buckle or Chromium Nitride PVD coated stainless steel

Vegan Leather Band

Microfiber Polyurethane

The E4 and Embrace serve two different purposes and are designed for two different types of users.

Embrace is optimized to detect unusual movement patterns and changes in physiological signals that could be associated with convulsive seizure. Its companion app, Alert App, notifies caregivers when Embrace has detected a possible tonic-clonic seizure.

The E4, on the other hand, is designed specifically for researchers looking to gather physiological signals in real-time and perform after-the-fact analysis. Wedon'trecommend it for consumers as the data is not summarized, and requires experience in data analysis to understand. For larger studies, the Embrace can also be used as a research tool, but would require a subscription for raw data exportation, while the E4 does not require a prescription.

Use

In addition to monitoring and alerting for possible tonic-clonic seizures, Embrace can also track rest and physical activity.

The portability of the E4 wristband allows researchers to either record physiological signals in at-home settings or in the lab. After recording, they can easily access the data for more in-depth analysis. With our developer tools, they can even build their own app using real-time E4 data.

For sample projects visit https://developer.empatica.com.

The apps associated with each device are different. E4 software does not work with Embrace and vice versa.

EMBRACE

E4 WRISTBAND

USAGE

Epilepsy Monitor

Sleep and Rest Management

Physical Activity tracking

Lab and Home Recording

Real-time Clinical Observation

Raw data Analysis

Real-time Data in your App

SENSORS

EDA (GSR)

3-Axis Gyroscope

3-Axis Accelerometer

Thermometer

EDA (GSR)

PPG

3-Axis Accelerometer

Infrared Thermopile

FEATURES

Water Resistant

Analog-like Watch

Interchangeable Band

Splash Resistant

Event Marker

60+ Hours Flash Memory

DATA TRANSFER

Bluetooth Smart

Bluetooth Smart

USB 2.0

BATTERY LIFE

24 to 30 hours (original Embrace)

48+ hours (Embrace2)

20+ Hours Streaming Mode

36+ Hours Memory Mode

FORM FACTOR

Case: 37x30x10 mm

Wrist: 100 - 210 mm

Weight: 17g

Case: 44x40x16 mm

Wrist: 110 - 190 mm

Weight: 25g

INTEGRATIONS

None

iOS and Android SDK

Windows TCP Server

PRICE

249.00$

Research software and pricing available on request

1,690.00$

Volume and Academic discounts available

Embrace is comprised of the following sensors: 1) EDA sensor: measures the constantly fluctuating changes in certain electrical properties of the skin, resulting from sweat secretion and sweat gland activity. EDA is activated by regions deep in the brain involved in emotion such as fear, anxiety and positive excitement. 2) Accelerometer: detects motion and orientation. 3) Gyroscope: measures rotation and angular momentum. 4) Peripheral Temperature Sensor: measures skin surface temperature.

Learn more about Embrace specifications

.

You can wear Embrace while exercising, in the rain, or taking a shower. You can also swim with it in pools (no saltwater). You shouldnt submerge Embrace in water that is deeper than 3.3 feet or 1m. Also, it shouldnt be worn in a hot tub.

Please note that Bluetooth connectivity will not work if Embrace is submerged in water, and thus alerts cannot be sent to caregivers.

We advise you to clean Embrace regularly following the instructions here: How to clean my Embrace

If your tracking number states that the package has been delivered, but youcan'tfind it, please follow the instructions below:

Verify the shipping address in your Empatica Account.

Look for a notice of an attempted delivery near your door or mailbox.

Carefully inspect the locationwhere your package was supposed to be delivered. Sometimes packages are delivered in a discrete location such as under a doormat.

Contact the courier listed in the shipment confirmation email to track the package.

If you'd like to change the color, quantity or type of band purchased, we recommend that you email us requesting that we cancel your order, so you can proceed with purchasing another. Unfortunately, it isn't possible to change this through your Empatica account.

You may however be able to edit your shipping address based on your order status. If your order status is listed as Not Scheduled, you'll be able to edit the shipping address, so long as it is within the same country (due to the possible difference in shipping charges).

For instructions on how to edit the shipping address, please read: How can I edit the shipping address on my order?

To update your profile, follow these steps:

1. Log in to your Empatica Account.

2. Go to the Profile section.

3. Make the desired changes, and then click on Update my profile.

Note: Ifyou'vedecided to update your email address, you must verify the new email first. Youll receive an email from us after you submit the new email address. Just click on the button in the email to verify the address.

To orderEmbrace2, please follow the steps below:

Go to our online store.

Choose the color youd like, and any additional bands to personalize your look.

Click on Order Now.

A window will pop-up with your order. If everything is correct, click on Check out.

Insert your shipping details.

Proceed with payment.

Check your inbox for an email from us asking you to create your Empatica Account. Click on the link in the email.

Create your Empatica Account where you can check the status of your order.

For the US only: Before we can ship the device to you, you must upload a valid prescription from a healthcare practitioner for us to review. When approved, we'll proceed with the shipping process. For more information on how to upload it, follow these instructions.

You can easily check the time on your Embrace. Once, Embrace as been paired with your phone, it will automatically sync with the time on your phone.

To check the time:

Tap once on the watch face.

The blue light indicates the hour, while the flashing white light indicates the minutes.

Light & Vibration

If youcan'tsee the time on your Embrace, please check if the mode is off.

We understand the importance in making sure that Embrace is the right device for your child's needs. Here you can find answers to the most common questions asked by parents.

Is it suitable for my child?

The Embrace2 has been FDA-cleared for children ages 6 and up. We highly encourage you to consult your doctor to determine if Embrace is right for the needs of your child. If your child is younger than 6, they'll need a prescription from their doctor for off-label use.

article

Will the wristband fit?

The Embrace should fit snugly on the wrist, but not too tight. We offer two different sizes so you can find the one that suits your child best.

Grey stretchable band: Expands from 10cm at its smallest to 20 cm at its largest (4 to 8 inches).

Black and blue stretchable band: 13 to 25 cm (about 5 to 10 inches) in circumference.

Does my child need a smartphone?

We highly recommend that your child has a dedicated smartphone or tablet with Bluetooth and internet connection. This is because Embrace needs to be within Bluetooth range (about 30 feet or 10 meters) of the smartphone at all times in order to send Alerts when it detects a possible tonic-clonic seizure.

Tip

It can be tricky to keep Embrace within the Bluetooth range of the paired smartphone when the Embrace user is a young child. We suggest using a running belt to hold the smartphone to make sure that the two devices are always within range.

What about school?

It is important that teachers know what Embrace does and that your child will always have to have their phone with them. Here you can find a nice with some useful tips on how to use Embrace at school.

Embraces seizure monitoring is based on an algorithm weve developed that is designed to recognize unusual movements, electrodermal activity variation, and peripheral temperature.

Most devices on the market consider two threads of information: duration and intensity of your movements. Instead, Embrace takes into account additional variables, such as skin temperature and electrodermal activity variations, that accompany tonic-clonic seizures. In addition, we created our algorithm using advanced machine learning methods, trained on data collected in epilepsy monitoring units in hospitals.

To learn more about the algorithm Embrace uses to detect unusual patterns in movement and physiological signals we recommend this article: Event detection accuracy

We also encourage you to learn more about how Embrace works.

If you believe that your package may have been lost while in transit, please follow the instructions below:

Verify the tracking number and delivery address.

Double-check that your package has not been left at the porch, the front desk of your apartment building, office, or with a neighbor.

Contact the courier and provide them with the tracking number so that they can try and locate the package.

If youre still unable to locate it, please reach out to [email protected] and provide us with the tracking number, and we'll further investigate.

To get the best performance from your Embrace, always make sure to update the firmware whenever a new version is available. The firmware houses new features and improvements to the functionality of your watch.

Before updating the firmware, make sure that:

Embrace is placed in the charger

Embrace has at least 30% memory*

Embrace is placed next to its paired smartphone

The paired smartphone is connected to internet

The Alert App is open in the foreground

To automatically update the firmware

Youll receive a notification through the Alert App whenever a new version of the firmware is available. Tap on this notification to start the update.

To manually upgrade the firmware

1. Open the Alert App>>More>>Embrace Settings>>Embrace Updates.

2. If new firmware is available, tap Update Now (If no update is available, you will see Up to date).

3.Tap on the firmware version displayed on the next screen.

4.In the next pop-up, tap Yes, upgrade!

5. The update should take around 5 to 10 minutes.

If you run into any issues along the way, please email us at [email protected].

*To check the memory go toAlert app>>More>>Settings>>Advanced Settings>>Embrace Memory.

In this article, you can find samples and information about the contents of your downloaded data files.

Common files

README.txt: contains information about the package content and query information.

UPLOAD_STATUS.txt: shows the data upload status of all the Embrace devices paired with the subjects enrolled in the study during the requested time interval. See an example below:

Subject Compliance Reports

metadata.csv: shows timing information and the Embrace settings during the considered time window (Date and time in UTC, Timezone, Firmware version, App name, App version, OS Version, Seizure model). If it contains more than one row, it means that a column has changed during the considered duration (e.g., change in the timezone or firmware update). See an example below:

Sensors Data

In each file, the first column of the exported raw sensors data corresponds to the timestamp expressed as Unix Time in milliseconds (UTC), synced with the paired devices clock.

The following columns contain the raw data recorded by the sensors:

temp.csv:data from temperature sensor expressed in degrees on the Celsius (C) scale

eda.csv: data from the electrodermal activity sensor expressed in microsiemens (S)

acc.csv: data from 3-axis accelerometer sensor expressed as [g] unit. The accelerometer is configured to measure acceleration in the range [-16g, 16g]; data from x, y, and z axes are respectively in the second, third, and fourth columns.

Embrace EDA data - negative values

As any measurement instrument, Embrace is subject to accuracy, tolerance, and drift.

Sporadic negative EDA values can be observed in the range [-0.5S, 0S], while Embrace is on-wrist.

As per production tests, the absolute accuracy at 0 uS data point is [-0.5S, +0.5S] and 98.3% of the samples are in the [-0.01S, +0.01S] range.

Accuracy specs for the Embrace are [-0.5S, +0.5S] or 5% of the readings, whichever is larger.

The global quality of the EDA signal is not impacted since phasic variations of the signal remain unaltered. We suggest to consider the negative values as a very low physiological skin conductance signal.

Dummy data examples:

temp.csv

eda.csv

acc.csv

Summary Data

The summary.csv is a spreadsheet that provides a synopsis of all the raw sensor data mentioned above in one file, aggregated by the minute. It includes the following information:

Datetime (UTC) with 1 minute resolution, e.g. 2019-01-01T23:49:00Z

Timezone (minutes),e.g. 60 (which means the data was recorded in UTC+1 timezone)

Acceleration magnitude average [normalized by g] over a minute

EDA- 1 minute averages expressed as microsiemens [S]

Skin temperature- 1 minute averages expressed as degrees Celsius (C)

Movement intensity - an integer value as an arbitrary unit calculated by Empaticas Physical Activity Algorithm. It can assume values in the range [0-180] and represent the amount of movement over a minute. The higher the value, the more intense the activity.

Steps count - integer value calculated by Empaticas Physical Activity Algorithm that represents the footsteps count over a minute.

Rest- classification of rest period according to Empaticas Sleep Detection Algorithm. Values are as follows:

0=No-sleep; 1=Sleep; 2=Turns & Tosses; 3=Interruption

On Wrist flag - boolean value resulting from the analysis of Empaticas compliance detection algorithm

TRUE if the Embrace has been worn correctly, FALSE if otherwise

Below is an example of the summary.csv file:

Seizure/Autonomic Arousal/Custom Event Reports

The exported spreadsheet (.CSV format) of the subjects reported events include the following information:

Site ID

Enrollment ID

Date and time (UTC)

Timezone (minutes)

Duration of the event (seconds)

Subjects' notes

Creation (for seizure studies: detected or manual)

The report can provide you with important contextual information on the subjects circumstances at the time of the event, including duration, possible triggers, and any other pertinent information that subjects note. In line with this, you may check the relevant raw data for any patterns and further analysis.

Below are examples of the different reports you can download according to the study.

Seizure report:

Autonomic arousal report:

Generic event report:

Please note that the file will contain all the seizures or events experienced by all subjects for the whole duration of their enrollment.

If youd like to view and download the report from a specific subject per month, you can do so by going directly to the Subject Overview Page. You can find more info here:

Embrace2 takes around 1 hour and 20 minutes to charge and will last around 48 hours. The original Embrace takes around 1 hour and 40 minutes to charge, but lasts 24-30 hours.

Remember that while Embrace is charging, you should have someone around that can provide help in the event of a seizure.

To charge your Embrace follow these steps:

Step 1: Connect the charging dock to a powered USB port on a computer, a USB wall socket, or a USB Power adapter connected to a power source.

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Step 2: Make sure the heart symbol matches the heart on the charging dock. If you cannot see the symbol, simply make sure the sensorson the bottom of the device fit into the dents.

Step 3: Within 20 seconds, an orange light will fill the LED circle on Embrace until the battery is fully charged. At this point, the light will turn green indicating your Embrace is fully charged.

If your Embrace battery was completely drained, it will reboot when placed in the charger. A white circle will light up a few seconds after connecting the device to the charger.

If you're having trouble charging, please try the below tips:

Adjust Embrace slightly in the charger to ensure proper contact.

Try charging Embrace with a different USB cable.

Charge Embrace using a different power source.

Clean the charging dents and the electrodes on the back using a dry cleaning cloth to remove any dust or accumulated dirt.

Tips to maximize Embraces battery life:

Dont leave Embrace discharged for an extended period of time (beyond 2 weeks). This may damage the battery.

Avoid charging Embrace in extreme temperaturesbelow 32F and above 113 F (below 0 C and above 45 C).

In fact, even leaving your Embrace in extreme temperatures may damage its battery capacity. In very cold temperatures, the battery may not last as long, but this is temporary, and will return back to normal when temperatures have increased. Very hot temperatures may decrease its battery capacity.

If the above steps haven't worked for you, please reach out to us at .

Electrodermal activity (EDA) also known as skin conductance or galvanic skin response, is when the skin conducts electricity through the sweat glands, and can tell us a lot about the state of the body and mind.

Most commonly, its used to detect stress levels and tends to increase with emotional or physical arousal.

Significant EDA responses have also been shown to be correlated with tonic-clonic seizures. In fact, its something that our Chief Scientist, and Co-Founder, Dr. Rosalind Picard discovered during one of her studies. This discovery inspired us to build a significantly more accurate method of detecting tonic-clonic seizures.

What affects EDA?

Several factors can raise your EDA, such as physical activity, excitement, and stress. EDA can also fluctuate based on daily water intake and with certain medication. The measurements of EDA can be affected by skin hydration, and where the sensors are placed.

How does Embrace measure EDA?

The electrodes on the back are in constant contact with the skin and can measure the subtle changes of electrical current passing through the skin.

What role does EDA play in our seizure monitoring algorithm?

EDA helps make our algorithm more precise, and less likely to trigger false alarms, than relying solely on movement data. We continue to analyze characteristic EDA signatures of tonic-clonic seizures to continually improve our algorithm.

Embrace works by using Bluetooth and internet to alert caregivers when it detects a possible tonic-clonic seizure. Aside from monitoring for possible tonic-clonic seizures, Bluetooth and Internet are also necessary to track your rest and physical activity in the Mate App.

Embrace requires the following components to work:

A compatible smartphone/tablet

Alert App

Mate App

A subscription plan

Internet connection

Throughout the day, Embrace uses its sensors to log a range of data about your physical and physiological activity. This includes the number of steps you take, distance covered, intensity of your movement, and fluctuations in electrodermal activity and skin temperature. It can also detect periods of rest, turns and tosses, and interruptions in sleep.

It automatically transmits this data to the Alert App on its paired smartphone using Bluetooth. This is why the paired smartphone must always stay close to Embrace (within 30 feet/10 meters) and within a clear range of sight (no obstructions such as walls, doors, etc.). From the Alert App, the data goes to our servers for processing. Once its processed, it goes to your Mate App so you can view the important statistics of your day.

For seizure monitoring and alerting, Embrace uses an algorithm to look for motions and physiological activity that indicates a possible tonic-clonic seizure. Alerts (SMS and phone calls) are sent to caregivers from the Alert App through internet.

Remember: Both Bluetooth and internet connection are necessary for the Alert notifications to be sent when Embrace detects a possible tonic-clonic seizure.

What happens when there is a Bluetooth disconnection?

Embrace communicates with your paired phone using Bluetooth. So when thereisn'ta Bluetooth connection, Embracecan'ttell your phone to call your caregivers when it detects a possible seizure.

However, it can still log data about your movement and rest. Only that it will be stored on its internal memory, instead of going to the Alert App. It can hold up to 14 hours on its internal memory.

Beyond this, itwon'tbe able to record any more rest or physical activity. Then, as soon as the Bluetooth connection is restored, the data will start to offload onto the Alert App, freeing up the memory on Embrace.

What happens if the smartphone isn't connected to the internet?

Most importantly, the Alert Appwon'tbe able to send alert SMS and calls to your caregivers.

Secondly, the data stored on the Alert Appwon'tbe able to travel to our servers for processing. Instead, it will remain in the Alert App until the internet connection is restored.

Remember that airplane mode disables internet connection and Bluetooth.

If you're curious about how Embrace's seizure monitoring algorithm works to identify possible tonic-clonic seizures, we recommend reading: Embrace's seizure monitoring system.

If your Embracewon'tpair with your phone/tablet try the following tips:

Check that Embrace is charged.

Check that Bluetooth is turned on.

Check that your phone is connected to internet (try opening a website to make sure youre connected).

Make sure that your phone/device is running the minimal software required (Android 5.0 or iOS 10).

If all of the above are true, and youre still not able to pair follow the below instructions based on your mobile device platform.

Android devices

Make sure you have the latest version of the Alert App.

Enable location services (Settings>Scroll down to Location>tap location> tap On. (If it's already on, toggle it on and off a few times).

Forget the Embrace from your smartphones Bluetooth settings (Settings>Bluetooth. Find Embrace on on the list of available or paired devices, then tap forget).

Open the Alert App, sign in and follow the instructions to pair.

If you're asked for a pin, enter 123456.

If you still cannot pair Embrace, toggle Bluetooth on and off and repeat the procedure.

You can also clear the Bluetooth cache on your phone, and try pairing again. Steps to clear the Bluetooth cache may vary from phone to phone, but you can find some guidelines here.

Note: Some Android devices may list Bluetooth 4.0, but do not actually support Bluetooth Low Energy. Check with the phone manufacturer if youre not certain.

iOS devices

Force stop the Alert App.

In your smartphone, go to settings > Bluetooth > Tap on the i beside the Embrace > Forget this device.

Toggle Bluetooth on and off a few times.

Relaunch the Alert App.

Follow the instructions to pair.

If the above steps do not work, reboot your phone and try again.

Ifyou'vepreviously paired your Embrace watch with a different smartphone, please make sure to remove Embrace from the Bluetooth settings of the previous device.

If you have 2 Alert App accounts, please unpair Embrace from the previous account and try again using the account you would like to pair with.

The Yellow Cross flashing on your Embrace indicates that its internal memory is full. This means that Embrace was disconnected from the paired smartphone for longer than 14 hours.

It will still be able to detect and alert for possible tonic-clonic seizures, but it won't be able to record any additional sleep or physical activity data. Therefore, the data on Embrace needs to be transferred to its paired phone.

To free the memory:

Keep Embrace close to the paired phone, and the data should transfer automatically.

Note: It may take up to 2 hours to transfer all the data. You can check if the data transfer has initiated by checking the memory level of your Embrace in the Alert App (Alert App>>Settings>>Embrace Settings>>Embrace Memory).

If the dataisn'ttransferring:

-Make sure that Bluetooth is on.

-If Bluetooth is already on, turn it off and then on again.

-Kill the Alert App, and then relaunch it. Every time you open the app it should initiate a sync.

-Restart your phone. This old faithful trick can sometimes solve mysterious problems.

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Ifyou'vetried all of the above tips, and the memory stillisn'tfreeing up, please contact us at .

The Mate App works in conjunction with Embrace2 to create a mobile data acquisition system designed for study subjects. It automatically transfers data collected from subjects to Empaticas servers for processing. Researchers are then able to view their subjects' data in the Research Portal for further analysis. After the data has been processed, rest and physical activity results are returned to the subjects for visualization inside the Mate App.

Custom event diary

The Mate App is the perfect replacement for unreliable paper diaries. Mate allows subjects to log any seizures they may have experienced, or any other custom events that are relevant to the study. This information is then automatically transferred to the Research Portal for your viewing, providing you with complementary information about the circumstances of their events.

Unique log-in

Subjects will log into the app with unique uploader credentials, generated by the Research Portal. Researchers can agree on a specific subject ID for each patient before starting the enrollment process. This is convenient as it de-identifies your subjects and so none of their personal data is shared. The unique identifier ensures that the subject's data is always grouped correctly and stored securely.

Data transfer with the Mate App

Embrace2 continuously records your subjects physiological data. This data syncs with the Mate App using Bluetooth connectivity. From the Mate App, the data is then transferred to our servers.

When Embrace2 is out of Bluetooth range or if the Bluetooth is disabled, it can store up to 14 hours of data in its memory. Its important that the subjects connect the device to the paired smartphone so the data can then automatically transfer to the Mate App.

Data stored in the Mate App will then be transferred to Empaticas servers using internet connection. This data flows seamlessly from the Mate App to our cloud, which you will then be able to review in the Research Portal.

Rest and physical activity tracking

Mate allows subjects to view an in-depth analysis of their rest and physical activity. Rest is analyzed to reveal how fragmented and efficient the rest period was. Physical activity is arranged into intensity, duration, distance, and step count. The app displays all of this information in one place, making it easy to see the overall activity of the day at a glance. These factors can help you with increasing the subjects compliance.

You can download the Mate App here:

Android for iOS and

You can purchase the E4 wristband through our online store or by contacting our sales team. We'll outline both methods below.

Online store

Purchasing online allows you to receive faster shipping (usually within 7 days, rather than 2-3 weeks).

Please visit our E4 page at this link and enter your billing and shipping details and indicate the quantity of E4s you'd like. At the moment, the modes of payment accepted for online purchases are credit card and PayPal. Note: We offer an academic discount of 18% for all university purchases. Just email [email protected] to request the discount code to be used at checkout.

Offline sale

Whenever an E4 sale is completed outside of our online store, the entity handling the transaction will be our Italian branch, Empatica Srl. You can find useful documents related to Empatica Srl for your vendor submission at this link. Please note that offline sales must comply with Italian invoicing regulations. Therefore, all quotes and invoices will be issued in EUR. If its necessary to include USD pricing in the PO, please use a fixed 1:1.13 EUR/USD exchange rate to calculate the counter value. The first step to start the purchase process is to request an official quote from our sales team ( [email protected] ). The request must indicate:

The number of E4s you would like to order

Your shipping and billing address

Your institution/company's name and VAT number (EU-only)

Contact's name, email address and phone number

Purchase order

To ensure fast processing, all purchase orders will have to:

Clearly refer to our quote number

Display the same pricing as per our offer: kindly note that volume discounts may change if the amount of devices ordered differs from the amount listed on the quote. For more information please refer to the pricing listed on our website.

Include shipping fees

Any purchase order that does not comply with the above instructions will not be processed. Please note that in advance payment terms are default for any sale that does not refer to an official PO sent by your institution.

Payment in advance

It is possible to pay in advance for offline sales as well, either via credit card or wire transfer. To do so, please request a proforma invoice by writing an email to [email protected] indicating:

The number of E4s you would like to order

Your shipping and billing address

Your institution/company's name and VAT number (EU-only)

Contact's name, email address and phone number

Preferred payment method

Since the E4 is a made-to-order device, please note that purchaseswon'tbe processed until a valid remittance advice is forwarded to the sales representative you have been in contact with. For any questions or concerns regarding offline sales, please do not hesitate to contact our Sales team at [email protected].

The E4 comes equipped with a single button to support interactions. You can trigger differentE4 actionsdepending on the duration of the button press.

button interaction notes

Short press: A short press is a quick click on the button (similar toclicking on a keyboard, trackpad or mouse button).

Standard Press: A standard press can be triggered by holding down the button between about one and three seconds.

Long Press: A long press can be triggered by holding down the button for more than five seconds.

When the E4 is powered off and disconnected from USB

Short press - From the OFF state a short pressure will not result in any output from the E4.

Standard press - Power on the E4. Press and hold the button until you see the green status LED switch on indicating that the E4 has entered Standby Mode. Assoon as you see the light you can release the button and the normal pressure is completed. The green status LED will pulse while the device is in standby mode. While the E4 is in standby mode you can connect it to a mobile device to enter Streaming Mode (indicated by a blue LED light) or wait for ~60 seconds for the device to enter Recording Mode (indicated by a red LED light).

When the E4 is powered on in Recording Mode

During start-up - as the E4 enters recording mode theredLED will pulse for ~20 seconds before going dark.

Short Press - create and event mark. The red LED will come on for 1 second indicating the Event Mark has been recorded.

Standard Press - You can turn off the E4with a standard press. Assoon as you click the button the ledturns on and then off after a second. As soon as the led is off you can release the button. The E4 now turned off.

Long Press - device reset.A successful "Reset"is indicatedsolid white light.NOTE: After a reset the device may need to be connected to USB to re-activate it.

When the E4 is powered on in StreamingMode

During start-up - after the streaming connection is first established theblueLED will pulse for ~20 seconds before going dark.

Short Press - create and event mark. Theblue LEDwill come on for 1 second indicating the Event Mark has been recorded.

Standard Press - You can turn off the E4with a standard press. Assoon as you click the button the ledturns on and then off after a second. As soon as the led is off you can release the button. The E4 should now be powered down.

Long Press - device reset.A successful "Reset"is indicatedsolid white light. NOTE: After a reset the device may need to be connected to USB to re-activate it.

When you power on the E4, make sure that the E4 starts in Standby Mode flashing green, which means that it is ready for use.

Error states are indicated by the following color combinations:

Flashing green and redindicates that the E4's memory is full or the clock is unset preventing you from operating the device in Memory Mode. You can still connect to the E4 from the E4 realtime app on your smartphone/tablet.

Flashing green and yellowLED lights indicate that the E4has a low battery and should be charged soon.

USB Connections

Connecting E4 to E4 manager via the USB charging cradle - the device enters Standby Mode (green LED); if there is data in memory the data transfer will commence indicated by alternating yellow and purple LED lights.

The E4 may alternate flashinggreenandyellowafter connecting it to a USB power source when attempting to transfer data. Charge the E4 for several minutes, disconnect, and reconnect to initiate the transfer of data.

Charging the E4 - the E4 can be charged by most powered USB connections (5V). When connected, the yellow LED light indicates that the E4 is charging. The yellow light stays on until the battery is charged.

Memory erase after uploading data - flashing light blue LED. Onceyou'veuploaded all the sessions from the E4 wristband through E4 manager, the device will flash light blue LED indicating the memory is in the clearing process. It takes up to 2 minutes to clear all the data if E4's internal memory was full and the light blue LED will disappear as soon as the E4 is disconnected from the USB port.

Memory erase in progress, E4 charging - flashing light blue and yellow LED. The yellow LED will stop flashing as soon as E4 is fully charged. Light blue LED will disappear as soon as the E4 is disconnected from the USB port.

Session download in progress - flashing purple LED.

Firmware upgrade in progress - flashingpurpleLED. Please note that while upgrading firmware, E4 wristband is not uploading data to the E4 connect. As soon as the firmware upgrade is completed, E4 will power down. Please turn the E4 wristband on to start session download.

Were sorry youre thinking of leaving us. If you werent happy with your service, wed love the chance to correct the situation.

Please email us at [email protected] or call us at 1-866-739-2049. Were always here to help!

As you may know your subscription plan is automatically renewed every month or year, depending on your payment plan.

To disable auto-renewal, please follow the instructions below. We also ask that you give us a few days notice before your next payment is due.

Sign in to https://myembrace.empatica.com/

Go to Account in the top right corner.

Scroll just a bit to Your subscription.

Click on View my subscription details.

On the next page, under Active Subscription, click on Disable auto-renewal.

Youll arrive at a new page. Well ask you a few questions to better understand how we can improve. This is necessary in order to cancel. Click Disable auto-renewal on this page to start the questions.

Submit the form, and well cancel your plan within 2 business days.

Please note:

Seizure monitoring and alerts are not available without a subscription plan.

Getting a refund for your subscription:

The subscription plan is non-refundable. However, youll still be able to use your plan until the day that it is set to bill next. For example, if you have an annual plan, and you cancel in the middle of the year, youll be able to use your plan until the year is up, but youwon'tbe billed for the following year.

Since the original version of Embrace has been discontinued, perhaps youre considering upgrading to Embrace2, and would like to know how it differs from the original.

First, lets start with whats the same.

Same sophisticated sensor technology

Both versions contain the same sensors used to monitor movement patterns and physiological signals that may be associated with tonic-clonic seizures.

Same alerting functionality

Both will trigger an SMS and phone call when an unusual pattern in movement and physiological signals is detected.

Different battery

Embrace2 comes with a superior battery life, lasting 44-48 hours. It takes around 1 hour and 20 minutes to fully charge. If you only need coverage for one day, a 30-minute charge is all it takes.

The original Embrace covers you for 24 to 30 hours and around 1 hour and 40 minutes to charge.

Different watch face

Embrace2 features 4 engraved hour indicators making it easier to read the time, while the original only has the heart in the 3 oclock position.

Prescription required for the US

In the US, a prescription is required for Embrace2 before we can ship, as it has been cleared by the FDA as a medical device.

If you would like to buy an Embrace2 and/or a subscription plan for a client (for instance, if you represent a charity organization or a care home) please follow the steps below:

Purchasing Embrace2 for your client

1. Place the order on our online store.

2. In the email field, enter the client's email address, as well as their phone number and shipping address.

[email protected]

3. After placing the order, the client will receive an order confirmation email, followed by an email to set up their Empatica Account. Please advise your client to look out for these emails.

4. Once the client has set up their Empatica Account, they'll have to upload a prescription for Embrace2. This is a necessary step in order to ship Embrace to the United States, as Embrace2 is an FDA-cleared device.

5. It will take us up to 5 business days to review the prescription. Once it has been approved, we'll ship Embrace2 within 5-7 business days.

Purchasing a subscription plan for your client

You can purchase an annual subscription plan for your client by using your Credit Card. Please contact Empatica Support team at to have the invoice sent to your email address. Please include the following information in your email: - Organization name - Billing address - Email address (to which invoice can be sent) - Type of annual plan you would like to purchase (Lite, Standard or Plus) Note: Third party providers can purchase only annual subscription plans for their clients, no monthly billing is supported at this time.

Your Site Manager can register (enroll) your Study participants (Subjects) through the Site Overview Page on the Research Portal.

Before the subjects enrollment visit, please make sure you prepare the equipment:

Fully charge Embrace.

If youre providing the Subject with a smartphone/iPod, charge the device. Otherwise, ask the Subject to charge the smartphone they will be using with Embrace.

Download the Mate App on the device that the Subject will be using with the Embrace watch.

You can print a checklist here: Subject Enrollment List

During the Subject enrollment visit, you can create the Subject on the Research Portal and log them into the Mate App.

Creating Subject on the Research Portal

Log in to the Empatica Research Portal and open the Site Overview Page.

Click on New Enrollment on the upper right corner.

Enter Subject Unique Identifier (pre-defined by the Organization).

Click Create Subject.

Early Term or Complete

At this point, the status of the Subject on the Research Portal will be Screening. It means that the Subject is still on the enrollment stage and that they have not been logged in to the Mate App yet.

Logging the Subject in to the Mate App

In the Research Portal:

Navigate to the desired Study, Site, and select the Subject, opening the Subject Overview Page.

Click on Start to generate the unique Mate App credentials. Please note that you will be required to enter your own credentials before you can generate the Subjects password.

Once you click Generate Password, a pop-up window will appear with the credentials (email address and password) and the QR code.

In the Mate App:

4. Now, open the Mate App on the Subjects smartphone/iPod tap on Research Study Login.

5. You can now log the Subject in by using either the QR code, with the generated email address and password.

6. Once the Subject is logged in to the Mate App, you can with pairing the Embrace watch following the in-app instructions.

7. The Subject is all set up once the Embrace is successfully paired.

Note:

Once you generate the login credentials, the Subjects status on the Research Portal will change from Screening to Active. Subject status will remain Active until you the subject.

Also note that Subjects will be automatically logged out of the Mate App when theydon'tuse it for 7 days. Please make sure to inform the subjects to connect to the Mate App and upload data regularly. You can decide to keep track of the login credentials for your Subjects for future reference. Otherwise, you can also generate a new password for the subject in the Research Portal.

The ways in which Empaticas devices can help revolutionize health are profound. Our goal is to provide advanced technological solutions to as many people as possible.

Empaticas devices, with its EDA sensors, have been used in previous studies to monitor the sympathetic nervous system. These studies used EDA in the fields of drug efficacy, addiction, stress, PTSD, feelings based on music, etc. You can find a selection of studies at the bottom of this article.

You can read more about the science behind Embrace here.

Bibliography

STRESS

Gouverneur, P., Jaworek-Korjakowska, J., Kping, L., Shirahama, K., Kleczek, P., & Grzegorzek, M. (2017). Classification of Physiological Data for Emotion Recognition. In Artificial Intelligence and Soft Computing (pp. 619627). Springer, Cham. https://doi.org/10.1007/978-3-319-59063-9_55

Winslow, B. D., Chadderdon, G. L., Dechmerowski, S. J., Jones, D. L., Kalkstein, S., Greene, J. L., & Gehrman, P. (2016). Development and Clinical Evaluation of an mHealth Application for Stress Management. Public Mental Health, 130. https://doi.org/10.3389/fpsyt.2016.00130

Gjoreski, M., Gjoreski, H., Lutrek, M., & Gams, M. (2016). Continuous Stress Detection Using a Wrist Device: In Laboratory and Real Life. In Proceedings of the 2016 ACM International Joint Conference on Pervasive and Ubiquitous Computing: Adjunct (pp. 11851193). New York, NY, USA: ACM. https://doi.org/10.1145/2968219.2968306

Mhlbacher-Karrer, S., Mosa, A. H., Faller, L. M., Ali, M., Hamid, R., Zangl, H., & Kyamakya, K. (2017). A Driver State Detection System-Combining a Capacitive Hand Detection Sensor With Physiological Sensors. IEEE Transactions on Instrumentation and Measurement, PP(99), 113. https://doi.org/10.1109/TIM.2016.2640458

Leonard, N. R., Silverman, M., Sherpa, D. P., Naegle, M. A., Kim, H., Coffman, D. L., & Ferdschneider, M. (2017). Mobile Health Technology Using a Wearable Sensorband for Female College Students With Problem Drinking: An Acceptability and Feasibility Study. JMIR MHealth and UHealth, 5(7), e90. https://doi.org/10.2196/mhealth.7399

Furberg, R. D., Taniguchi, T., Aagaard, B., Ortiz, A. M., Hegarty-Craver, M., Gilchrist, K. H., & Ridenour, T. A. (2017). Biometrics and Policing: A Protocol for Multichannel Sensor Data Collection and Exploratory Analysis of Contextualized Psychophysiological Response During Law Enforcement Operations. JMIR Research Protocols, 6(3), e44. https://doi.org/10.2196/resprot.7499

Winslow, B. D., Chadderdon, G. L., Dechmerowski, S. J., Jones, D. L., Kalkstein, S., Greene, J. L., & Gehrman, P. (2016). Development and Clinical Evaluation of an mHealth Application for Stress Management. Public Mental Health, 130. https://doi.org/10.3389/fpsyt.2016.00130

Miranda, D., Favela, J., & Ibarra, C. (2015). Detecting State Anxiety When Caring for People with Dementia. In J. Bravo, R. Hervs, & V. Villarreal (Eds.), Ambient Intelligence for Health (pp. 98109). Springer International Publishing. https://doi.org/10.1007/978-3-319-26508-7_10

Gaggioli, A., Pallavicini, F., Morganti, L., Serino, S., Scaratti, C., Briguglio, M., Riva, G. (2014). Experiential virtual scenarios with real-time monitoring (interreality) for the management of psychological stress: a block randomized controlled trial. Journal of Medical Internet Research, 16(7), e167. https://doi.org/10.2196/jmir.3235

Sevil, M., Hajizadeh, I., Samadi, S., Feng, J., Lazaro, C., Frantz, N., Cinar, A. (2017). Social and competition stress detection with wristband physiological signals. In 2017 IEEE 14th International Conference on Wearable and Implantable Body Sensor Networks (BSN) (pp. 3942). https://doi.org/10.1109/BSN.2017.7936002

PTSD

Holmgrd, C., Yannakakis, G. N., Martnez, H. P., Karstoft, K.-I., & Andersen, H. S. (2014). Multimodal PTSD characterization via the StartleMart game. Journal on Multimodal User Interfaces, 9(1), 315. https://doi.org/10.1007/s12193-014-0160-5

PAIN

Felipe, S., Singh, A., Bradley, C., Williams, A. C., & Bianchi-Berthouze, N. (2015). Roles for personal informatics in chronic pain. In Pervasive Computing Technologies for Healthcare (PervasiveHealth), 2015 9th International Conference on (pp. 161168). Istanbul, Turkey: IEEE.

Iranzo, R. M. G., Gom, J. V., & Pascual, F. V. (2016). Managing Emotions for the Treatment of Patients with Chronic Low Back Pain. In Proceedings of the XVII International Conference on Human Computer Interaction (pp. 30:130:2). New York, NY, USA: ACM. https://doi.org/10.1145/2998626.2998627

Koskimki, H., Mnttinen, H., Siirtola, P., Huttunen, H.-L., Halonen, R., & Rning, J. (2017). Early Detection of Migraine Attacks Based on Wearable Sensors: Experiences of Data Collection Using Empatica E4. In Proceedings of the 2017 ACM International Joint Conference on Pervasive and Ubiquitous Computing and Proceedings of the 2017 ACM International Symposium on Wearable Computers (pp. 506511). New York, NY, USA: ACM. https://doi.org/10.1145/3123024.3124434

EPILEPSY

Ramgopal, S., Thome-Souza, S., Jackson, M., Kadish, N. E., Snchez Fernndez, I., Klehm, J., Loddenkemper, T. (2014). Seizure detection, seizure prediction, and closed-loop warning systems in epilepsy. Epilepsy & Behavior, 37, 291307. https://doi.org/10.1016/j.yebeh.2014.06.023

Vandecasteele, K., De Cooman, T., Gu, Y., Cleeren, E., Claes, K., Paesschen, W. V., Hunyadi, B. (2017). Automated Epileptic Seizure Detection Based on Wearable ECG and PPG in a Hospital Environment. Sensors, 17(10), 2338. https://doi.org/10.3390/s17102338

Heldberg, B. E., Kautz, T., Leutheuser, H., Hopfengrtner, R., Kasper, B. S., & Eskofier, B. M. (2015). Using wearable sensors for semiology-independent seizure detection - towards ambulatory monitoring of epilepsy. In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 55935596). https://doi.org/10.1109/EMBC.2015.7319660

Van de Vel, A., Cuppens, K., Bonroy, B., Milosevic, M., Jansen, K., Van Huffel, S., Ceulemans, B. (2016). Non-EEG seizure detection systems and potential SUDEP prevention: State of the art: Review and update. Seizure, 41, 141153. https://doi.org/10.1016/j.seizure.2016.07.012

Ulate-Campos, A., Coughlin, F., Ganza-Lein, M., Fernndez, I. S., Pearl, P. L., & Loddenkemper, T. (2016). Automated seizure detection systems and their effectiveness for each type of seizure. Seizure, 40, 88101. https://doi.org/10.1016/j.seizure.2016.06.008

Cogan, D., Birjandtalab, J., Nourani, M., Harvey, J., & Nagaraddi, V. (2016). Multi-Biosignal Analysis for Epileptic Seizure Monitoring. International Journal of Neural Systems, 27(01), 1650031. https://doi.org/10.1142/S0129065716500313

DeGiorgio, C. M., Curtis, A., Hertling, D., & Moseley, B. D. (2019). Sudden unexpected death in epilepsy: Risk factors, biomarkers, and prevention. Acta Neurologica Scandinavica, 139(3), 220230. https://doi.org/10.1111/ane.13049

Stewart, C. L., Rashid, Z., Ranjan, Y., Sun, S., Dobson, R. J. B., & Folarin, A. A. (2018). RADAR-base: Major Depressive Disorder and Epilepsy Case Studies. In Proceedings of the 2018 ACM International Joint Conference and 2018 International Symposium on Pervasive and Ubiquitous Computing and Wearable Computers (pp. 17351743). New York, NY, USA: ACM. https://doi.org/10.1145/3267305.3267540

Zhao, X., & Lhatoo, S. D. (2018). Seizure detection: do current devices work? And when can they be useful? Current Neurology and Neuroscience Reports, 18(7), 40. https://doi.org/10.1007/s11910-018-0849-z

ADDICTION/CRAVINGS

Carreiro, Stephanie & Chai, Peter & Carey, Jen & Lai, Jeffrey & Smelson, David & Boyer, Edward. (2018). mHealth for the Detection and Intervention in Adolescent and Young Adult Substance Use Disorder. Current Addiction Reports. 5. 10.1007/s40429-018-0192-0.

Carreiro S, Smelson D, Ranney M, et al. Real-time mobile detection of drug use with wearable biosensors: a pilot study. J Med Toxicol. 2014;11(1):73-9.

Carreiro S, Wittbold K, Indic P, Fang H, Zhang J, Boyer EW. Wearable Biosensors to Detect Physiologic Change During Opioid Use. J Med Toxicol. 2016;12(3):255-62.

Carreiro S, Fang H, Zhang J, et al. iMStrong: Deployment of a Biosensor System to Detect Cocaine Use. J Med Syst. 2015;39(12):186.

Chintha KK, Indic P, Chapman B, Boyer EW, Carreiro S. Wearable Biosensors to Evaluate Recurrent Opioid Toxicity After Naloxone Administration: A Hilbert Transform Approach. Proc Annu Hawaii Int Conf Syst Sci. 2018;2018:3247-3252.

Leonard, N. R., Silverman, M., Sherpa, D. P., Naegle, M. A., Kim, H., Coffman, D. L., & Ferdschneider, M. (2017). Mobile Health Technology Using a Wearable Sensorband for Female College Students With Problem Drinking: An Acceptability and Feasibility Study. JMIR MHealth and UHealth, 5(7), e90. https://doi.org/10.2196/mhealth.7399

Md Shaad Mahmud, Hua Fang, Stephanie Carreiro, Honggang Wang, Edward W. Boyer. Wearables technology for drug abuse detection: A survey of recent advancement. Smart Health. 2018. https://doi.org/10.1016/j.smhl.2018.09.002.

Stroes, J. D. (2016). A feasibility study into measuring intraindividual alcohol craving in a longitudinal study: measuring self reported craving in a naturalistic setting combined with the usability of the Empatica E4 wristlet. (Bachelor's thesis, University of Twente). http://essay.utwente.nl/70233/

van Lier, H. G., Oberhagemann, M., Stroes, J. D., Enewoldsen, N. M., Pieterse, M. E., Schraagen, J. M. C., ... & Noordzij, M. L. (2017, April). Design Decisions for a Real Time, Alcohol Craving Study Using Physio-and Psychological Measures. International Conference on Persuasive Technology (pp. 3-15). Springer, Cham. http://link.springer.com/chapter/10.1007/978-3-319-55134-0_1

Plus this completed clinical trial on detecting opioid use: https://clinicaltrials.gov/ct2/show/NCT03462797

Singh, R., Lewis, B., Chapman, B., Carreiro, S., & Venkatasubramanian, K. (2019). A Machine Learning-based Approach for Collaborative Non-Adherence Detection during Opioid Abuse Surveillance using a Wearable Biosensor. Biomedical Engineering Systems and Technologies, International Joint Conference, BIOSTEC ... Revised Selected Papers. BIOSTEC (Conference), 5, 310318. https://doi.org/10.5220/0007382503100318

SLEEP

Sano, A., Picard, R. W., & Stickgold, R. (2014). Quantitative analysis of wrist electrodermal activity during sleep. International Journal of Psychophysiology: Official Journal of the International Organization of Psychophysiology, 94(3), 382389. https://doi.org/10.1016/j.ijpsycho.2014.09.011

Rani A. Sarkis, Nirajan Puri, Swapna Putta, Jonathan Pham, Chiara Caborni, Francesco Onorati, Giulia Regalia, Rosalind Picard, Milena Pavlova, Robert Stickgold. (2018) Sleep and Memory Consolidation in Older Patients with Epilepsy: a Neurophysiologic Analysis. AES-poster-2018-Abstract2.pdf

Siirtola, P., Koskimki, H., Mnttinen, H., & Rning, J. (2018). Using Sleep Time Data from Wearable Sensors for Early Detection of Migraine Attacks. Sensors (Basel, Switzerland), 18(5). https://doi.org/10.3390/s18051374

ENGAGEMENT

Gashi, S., Di Lascio, E., & Santini, S. (2019). Using Unobtrusive Wearable Sensors to Measure the Physiological Synchrony Between Presenters and Audience Members. Proc. ACM Interact. Mob. Wearable Ubiquitous Technol., 3(1), 13:113:19. https://doi.org/10.1145/3314400 a13-Gashi.pdf

DEMENTIA

Goodall G, Ciobanu I, Taraldsen K, Srgaard J, Marin A, Drghici R, Zamfir MV, Berteanu M, Maetzler W, Serrano JA

The Use of Virtual and Immersive Technology in Creating Personalized Multisensory Spaces for People Living With Dementia (SENSE-GARDEN): Protocol for a Multisite Before-After Trial

JMIR Res Protoc 2019;8(9):e14096 DOI: 10.2196/14096

SCHIZOPHRENIA

Cella, Matteo & Okruszek, ukasz & Lawrence, Megan & Zarlenga, Valerio & He, Zhimin. (2017). Using wearable technology to detect the autonomic signature of illness severity in schizophrenia. Schizophrenia Research. 195. 10.1016/j.schres.2017.09.028.

E4 connect is a secure cloud-based repository toreview and manage the data uploaded from the E4 wristband. It includes list and calendar views to navigate to a given session, a dashboard for data visualization and download links so you can access raw data with 3rd party applications.

E4 connect Features

Securely store session data from Empatica E4 devices.

Access data securely from an internet connected browser.

Export session packages to data in your prefered analytic software suite (e.g. MatLab),

View overview information for all recorded sessions uploaded to your account, including duration, device serial number, and session start date-time.

Search them by calendar date, device.

View your data

To access the Online Dashboard login to E4 connect

Click on "All Sessions" to get an overview of all recorded sessions.

Click on View to enter the dashboard of your session. how the data the can be exported

View your session

Export your data

E4 connect allows you to access raw data in CSV format for all of your Empatica data. To receive it just click on the CSV button.

Data can be downloaded using the Download button as a compressed directory (ZIP) containing text (CSV) formatted data and an explainer (info.txt) file.

TIP to learn more data export check our dedicated article on .

E4 connect currently offers data visualization but the most powerful insights will come from objective quantification of Empatica data. If you're looking for some tools for signal processing and analysis we can help! For systematic Skin Conductance analysis from our EDA files werecommend Ledalab (for MatLab). You may need to adjust skin conductance response (SCR) thresholds to account for lower magnitudes in typical wrist data. Instructions for importing Empatica E4 session data into Ledalab can be found in the appendixbelow. For heart rate variability (HRV) analysis we recommend Kubios (also for MatLab). Kubios takes ininstantaneous heart rate data and allows you to correct errant beats and conduct HRV analysis respectively.

REMINDERThe premium version of Kubios is the only version supporting E4 and CSV files as explained in Kubios User Guide.

If you prefer there are a number of signal processing toolkits available in the free software domain. Python's SciPy libraries have outstanding signal processing and data visualization capabilities. Importing data into Ledalab :

Before you begin please make sure to haveconfigured MatLab with Ledalab on your systemand recoded and downloaded some sessions using the E4.

Launch MatLab and point the command window at the Ledalab directory

Launch Ledalab

From the Ledalab "File" menu, select"Import Data" and then "Text Type 2"

Under the "Chose a text2 data-file" wizard, select "All Files" under the Enable menu at the bottom of the window

Confirm your sampling rate when prompted. Note the sampling rate can be found in the second row of the "eda.csv" file.

On import, the first row in the file (the UNIX start date-time) is used to configure the Y-Axis scale (SC [S]) so you will need to adjust the window to an appropriate level (on the order of 10-100 S depending on the data). The Y-Axis range window should be inthe upper right of the window as depicted in the image below.

For Skin Conductance response detection you should adjust the Ledalab settings to a S magnitude that is appropriate for your data. This should be somewhere between 0.05-0.5 S.